Antimalarial and antivectoral activities of traditionally. Assessment of antimalarial activity against plasmodium falciparum and phytochemical screening of some yemeni medicinal plants mohammed a. Page 9 g and an excellent source of vitamin c ascorbic acid. May 12, 2010 there is an urgent need to identify new antimalarial drug targets for both prophylaxis and chemotherapy, due to the increasing problem of drug resistance to malaria parasites. Antimalarial activity of two ethiopian medicinal plants. Medicinal plants play a key role in malaria control in africa, especially in remote areas where health facilities are limited. Malaria is endemic to the amazon region where plasmodium falciparum and plasmodium vivax. A search of cuban medicinal species with antimalarial activity is being developed in our laboratory. A key challenge in the use of medicinal plants in malaria treatment is the.
Rukungaa a centre for traditional medicine and drug research, kenya medical research institute, p. The archives of flora medicinal, an ancient pharmaceutical laboratory that supported ethnomedical research in brazil for more than 30 years, were searched for plants with antimalarial use. The strain was plated in duplicate using a synchronized culture at ringstage parasites, with a parasitaemia between 0. All six extracts were found to inhibit the growth of p. Products with antimalarial activity have been isolated from plants used against other parasites5,10 and some antimalarial natural products have shown good activity against a broad spectrum of parasites1. The aim of this study was to evaluate in vivo antimalarial activity of four plants. Antimalarial activities of some selected traditional herbs. In this study, phytochemical screening has been done using standard methods and the existence of. Therefore, the present study focused on the evaluation of in vivo antimalarial activities by the hydroalcoholic extracts of. Research article phytochemical analysis and antimalarial. This study therefore aimed at investigating the in vivo antiplasmodial activity of 80% methanol extract and solvent fractions of the leaves of croton macrostachyus h. Moreover, medicinal plants and herbs constitute most of the plant. Ex nees is traditionally used for the treatment of malaria and a study conducted previously on the crude leaf extract confirmed that the plant is endowed with antimalarial activity. Therefore in order to make health care accessible to 80% of rural people and now, increasingly urban people it is critical to sustain the medicinal plant resource base.
A search of cuban medicinal species with antimalarial activity is. Surveys have been conducted and plants have been selected to assess their antimalarial properties through in vitro and in vivo biological assays. In vivo antimalarial activity of the crude leaf extract. In vivo antimalarial activity was assessed using the 4day suppressive antimalarial assay. Extracts obtained from the leaves of annona muricata, ficus polita, luffa aegyptiaca, momordica charantia and newbouldia laevis and from the twigs and leaves of moringa pterygosperma were screened for antimalarial action against plasmodium falciparum cultured in vitro. In vivo antimalarial activity of solvent fractions of the. Erythrina schliebenii harms, holarrhena pubescens buchham, phyllanthus nummulariifolius poir, and caesalpinia. Results we have investigated eleven indian medicinal plants for their antihyperglycemic activity table 1. The current study was therefore designed to evaluate in vivo antimalarial activity and acute toxicity of selected medicinal plants. Antimalarial activity and in vivo toxicity of selected. In vivo, malaria, medicinal plants, plasmodium berghei.
Tome and principe stp islands in the gulf of guinea, aiming at identifying the most effective plants for further research. Dozens of these plants displayed antimalarial activity. Applications, trends, and prospects crc press book malaria is a potentially lifethreatening disease that affects millions worldwide, especially in subsaharan africa. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in turkey for antipyretic and analgesic purposes. The level of activity was discovered to be dose dependent, with the dose of 500 mg kg1 having the highest activity 75. To document the key medicinal plants used to treat malaria and examining the socioecological factors that influence their use, abundance and distribution. Sep 22, 2015 the in vivo antimalarial activity of aqueous extracts of the leaves of m. Investigation of some medicinal plants traditionally used.
Ten plants found in iran were selected by ethnobotanical survey of medicinal plants. In vitro antimalarial activity and cytotoxicity of some. Screening for in vitro and in vivo antimalarial activity of extracts of traditionally used plants from this region is a strategy for the discovery of new antimalarial substances 8910. Screening of naturalsynthetic compounds for antimalarial. Products with antimalarial activity have been isolated from plants used against other parasites 5,10 and some antimalarial natural products have shown good activity against a broad spectrum of parasites 1. Eight species, bathysa cuspidata, cosmos sulphureus, cecropia hololeuca. Tome and prncipe stp islands in the gulf of guinea, aiming at identifying the most effective plants for further research. The use of plant to meet healthcare needs has greatly increased worldwide in the recent times. Research article phytochemical analysis and antimalarial activity aqueous extract of lecaniodiscus cupanioides root mikhailolugbemironafiu,taoheedadedejiabdulsalam,andmusbauadewumiakanji department of biochemistry, university of ilorin, p. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. Some of them have been documented as having scientific and medicinal values. Malaria is endemic to the amazon region where plasmodium falciparum and. In vivo antimalarial activity of extracts of tanzanian. A rodent malaria parasite, plasmodium berghei, was used to inoculate healthy male swiss albino mice of age 68 weeks and weight 2327 g.
Plants may provide drugs directly such as quinine from cinchona bark or they may provide template molecules on which to base further new structures by organic synthesisartemisinin from artemisia. In vivo antimalarial activity of extracts of tanzanian medicinal plants used for the. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated. Investigation of some medicinal plants traditionally used for treatment of malaria in kenya as potential sources of antimalarial drugs c. The present study investigates the antimalarial activity of medicinal plants. Sixtynine extracts from 11 plant species were prepared and screened for in vitro activity against p. Traditional medicinal plants for the treatment and prevention. Antimalarial activity of selected malaysian medicinal plants. Assessment of in vivo antimalarial activities of some selected medicinal plants from turkey assessment of in vivo antimalarial activities of some selected medicinal plants from turkey ozbilgin, ahmet. This study investigated the antimalarial activity, toxicity and the nature of major chemical classes present in four medicinal plants. Pdf plants used in traditional medicine have been the source of a number of currently used antimalarial medicines and continue to be a. In vitro and in vivo antimalarial activity of plants. Phytochemical screening and in vivo antimalarial activity. The present study investigates the antimalarial activity of medicinal plants used in traditional medicine in s.
Phytochemical screening and in vivo antimalarial activity of extracts. Antimalarial activity of medicinal plants used in traditional. This study also assessed the conservation options available for these plants at community level. Pdf in vitro antimalarial activity of medicinal plant. In vivo antimalarial activity, toxicity and phytochemical. To identify medicinal plants which would provide potential lead compounds, this study evaluated the extracts of erythrina schliebenii harms fabaceae, holarrhena pubescens buchham apocynaceae, phyllanthus nummulariifolius poir euphorbiaceae, and caesalpinia bonducella l. Phytochemical analysis and antimalarial activity aqueous. There is an urgent need to identify new antimalarial drug targets for both prophylaxis and chemotherapy, due to the increasing problem of drug resistance to malaria parasites. Assessment of in vivo antimalarial activities of some. The percentage use of the herb by the giziga is as follows.
Alsllami3 and ulrike lindequist4 1department of microbiology, shphaco pharmaceutical ind. Antimalarial and antivectoral activities of traditionally used indigenous medicinal plants abstract malaria is the worldwide most important parasitic disease with an incidence of almost 300 millions clinical cases and over one million deaths per year. In order to assess their acclaimed potentials, eleven extracts were prepared from seven selected plants commonly used in western cameroon, and tested both for their antiplasmodial activity and cytotoxicity. Antimalarial efficacy and toxicological assessment of extracts of.
Medicinal plants used in traditional treatment of malaria. Antimalarial and toxicity studies are therefore important to validate anecdotal efficacy and safety reported by communities using these plants. In vivo antimalarial activity of extracts of tanzanian medicinal plants. The antimalarials quinine and artemisinin were isolated from traditionally used plants cinchona spp.
Forty plant species indicated to treat malaria were described by dr. The articles selected concern studies on ethnobotany. In the present study, the aim was to discover novel, effective plantbased extracts for the activity against malaria. The antiplasmodial activity was assessed using lactate. Using medicinal plants is a good alternative to modern antimalarial drugs, especially for the majority of those populations at. Therefore, the present study focused on the evaluation of in vivo antimalarial activities by the hydroalcoholic extracts of these two plants against plasmodium berghei in mice. Assessment of antimalarial activity against plasmodium. Plants used traditionally to treat malaria in brazil. I traditional medicinal plants for the treatment and prevention of human parasitic diseases merlin l willcox, benjamin gilbert encyclopedia of life support systems eolss many plants with antiparasitic properties, and often these plants contain several compounds which contribute together to this activity. In africa, the use of indigenous plants plays an important role in the traditional methods of malaria.
In vivo antimalarial effect of three medicinal plants 50% ethanol extracts 10 100 80 60 40 20 0 vitex negundo swertia anguistifolia phyllanthus niruri 30 drug doses mgkg body wt. In vivo antiplasmodial activity of two sahelian plant. Medicinal plants used in traditional treatment of malaria in. In vitro antiplasmodial activity and cytotoxicity of extracts. Traditional medicinal plants for the treatment and. In vitro and in vivo antimalarial activity of linolenic. In vivo antimalarial activity was determined by a 4day suppressive antimalarial assay according to waako et al. The objective of the present study was to investigate phytochemical components, antiplasmodial activity in vivo and evaluate the toxicity of two local medicinal plants, namely, salvadora persica l. Plants which have been used for centuries as alternative sources of medicine particularly in africa need to be explored for anti malaria activity in order to counteract the challenges associated with the disease 12. Antimalarial activity of some colombian medicinal plants.
The increasing global spread of drug resistance to most of the. In vitro antimalarial activity of six medicinal plants. Oct 22, 20 assessment of in vivo antimalarial activities of some selected medicinal plants from turkey assessment of in vivo antimalarial activities of some selected medicinal plants from turkey ozbilgin, ahmet. Sep 22, 2015 the use of plant to meet healthcare needs has greatly increased worldwide in the recent times. Comparative study of antimalarial effect of sambiloto. All this plants have been used traditionally for various purposes by the old folks. Invitro antimycobacterial activities of endophytic. In vitro antimalarial activity of medicinal plant extracts against plasmodium falciparum article pdf available in parasitology research 1081. In vivo antiplasmodial activity 4day suppressive tests was. Thus, we evaluated the antimalarial activity of three medicinal plants used in nigerian folklore for the treatment of malaria infection. Eyya sm, anthony dj, muhammad y, timothy w 2017 preliminary phytochemical analysis and in vivo antimalarial activity of the crude extracts of the leaf of african mistletoe tapinanthus dodoneifolius against plasmodium berghei in mice. In vitro antimalarial activity and cytotoxicity of.
Phytochemical screening and in vivo antimalarial activity of. Ilorin, nigeria correspondence should be addressed to mikhail olugbemiro na u. In vitro and in vivo antimalarial activity of boerhavia. In our antimalarial drug discovery program, we have evaluated more than 2,000 plant extracts against d6 and w2 strains of p. In vivo and in vitro antimalarial activity of vernonia amygdalina. Monteiro da silva flora medicinal leader and his coworkers. Antimalarial activity of medicinal plants used in traditional medicine in s. Screening of naturalsynthetic compounds for antimalarial activity plants have been used as a traditional medicine for the treatment of malaria. Pdf in vivo antimalarial activity of extracts of tanzanian medicinal. The search for new plantderived bioactive agents that can be explored for the treatment of drugresistant malaria infection is urgently needed. The in vivo antimalarial activity of aqueous extracts of the leaves of m. Antimalarial and antiplasmodial activity papaya leaves are made into tea as a treatment for malaria.
The current study was therefore designed to evaluate in vivo antimalarial activity and acute toxicity of selected medicinal plants collected from msambweni district, south coast. In vivo and in vitro antimalarial activity of vernonia. Flem caesalpiniacea for in vivo antimalarial activity in mice. This study was designed to evaluate the in vivo antimalarial activity and acute toxicity of selected medicinal plants commonly used in msambweni district, south coast of kenya for the treatment of malaria. Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in kenya were screened for their in vivo antimalarial activity in mice against a chloroquine cq resistant plasmodium berghei nk65, either alone or in combination with cq. Cryopreserved chloroquine sensitive plasmodium berghei anka strain were first revived and stabilized in mouse host according to ravindran et al.
Antimalarial activity and acute toxicity of four plants. Terrestrial plants have been demonstrated to be sources of antimalarial compounds. Arasit 50 100 aemia p 100 80 70 60 50 40 30 20 10 0 azadirachta indica. Resistant infections lead to increased necessity of searching novel drugs and drug combinations. In vitro and in vivo antimalarial activity of plants from. Oct 22, 20 resistant infections lead to increased necessity of searching novel drugs and drug combinations. Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in nigeria. In vivo antimalarial effect of three medicinal plants aqueous extracts ethanol extract 50% of 9 medicinal plants were tested in vitro for their antimalarial activities using cq sensitive isolate. Agbaje and onabanjo 1991 reported that aqueous extract of the plant e. The assessment of the in vitro antiplasmodial activity of cassia sieberiana leaves extracts showed a very good activity 100% of plasmodium elimination 4. Erythrina schliebenii harms, holarrhena pubescens buchham, phyllanthus nummulariifolius poir, and caesalpinia bonducella l. Pdf phytochemical screening and in vivo antimalarial activity of. In vitro antiplasmodial activity and cytotoxicity of. The recent emergence and spread of multidrug resistance in parts of southeast asia prompts the urgent need for novel and effective therapy against.
Antihyperglycemic activity of compounds isolated from. In vivo antimalarial activity of extracts of tanzanian medicinal plants used for the treatment of malaria ramadhani so nondo 1, paul erasto 2, mainen j moshi 1, abdallah zacharia 3, pax j masimba 1, abdul w kidukuli 1 1 department of biological and preclinical studies, institute of traditional medicine, muhimbili university of health and allied sciences, dar es salaam, tanzania 2 national. Increasing resistance of plasmodium falciparum to almost all the available antimalarial drugs urges a search for newer antimalarial drugs. The in vitro antiplasmodial activity and cytotoxicity of extracts from jatropha tanjorensis leaves. So, we included in our investigation, in addition to antimalarials and antipyretics, plant species used in our country as antiparasitic.
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